Hi Pravi,
Great question. Several things could predispose people to having a weakened immune system. Like Steph pointed out, obesity (and all the complications that go along with obesity such as heart disease, diabetes) contribute to a weak immune system. For example, a medic friend of mine routinely sees skin infections and cellulitis in her obese patients. Being diabetic on its own actually for u know reasons dramatically reduces immunity capacity. Certain genetic diseases like cystic fibrosis, or chronic granulomatous disease, also predispose people to poor immune function. However, the really worst thing to have is an autoimmune disease, where your body starts attacking itself for some reason, like with rheumatoid arthritis.
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